Mitochondrial
SS-31
A cell-permeable tetrapeptide that selectively localises to the inner mitochondrial membrane and binds cardiolipin; investigated for preserving cristae structure in mitochondrial disease research.
Also known as: Elamipretide, MTP-131
Quick facts
Molecular weight
640 Da
Half-life
3 h
Frequency
daily
Admins / wk
7
Routes
SubQ
Typical dose
1.00 mg–40.0 mg
Mechanism & positioning
A cell-permeable tetrapeptide that selectively localises to the inner mitochondrial membrane and binds cardiolipin; investigated for preserving cristae structure in mitochondrial disease research.
Researched for: cardiolipin stabilisation, mitochondrial cristae integrity, oxidative-stress reduction.
Reconstitution defaults
Default vial
10 mg
BAC water
2 mL
Concentration
5000 mcg/mL
Doses per vial
~10
Calculate with this peptide
References
- Szeto HH, Br J Pharmacol, 2014.
Related peptides in the Mitochondrial class
Frequently asked questions about SS-31
What is the typical research dose range for SS-31?
SS-31 is most commonly investigated at 1.00 mg–40.0 mg per administration, daily. Note: wide research range. These values reflect documented research-stage protocols and are not medical recommendations.
What is the half-life of SS-31?
SS-31 has an approximate plasma half-life of 3 hours. Practical steady state is reached after roughly five half-lives — about 1 days under continuous administration.
How is SS-31 administered in research protocols?
Published research uses subq administration. Typical reconstitution is 10 mg vial in 2 mL of bacteriostatic water, producing a concentration of 5000 mcg/mL.
What vial sizes are commonly available for SS-31?
Common stocked vial sizes are 10 mg. The 10 mg vial is the most-used default in published protocols.