Mitochondrial
MOTS-c
A 16-amino-acid peptide encoded within the mitochondrial 12S rRNA region; investigated as an exercise-mimetic regulator of AMPK and age-related metabolic decline.
Quick facts
Molecular weight
2,174 Da
Half-life
2.5 h
Frequency
weekly
Admins / wk
1
Routes
SubQ
Typical dose
5.00 mg–10.0 mg
Mechanism & positioning
A 16-amino-acid peptide encoded within the mitochondrial 12S rRNA region; investigated as an exercise-mimetic regulator of AMPK and age-related metabolic decline.
Researched for: AMPK pathway activation, mitochondrial function, exercise-mimetic signalling.
Reconstitution defaults
Default vial
10 mg
BAC water
2 mL
Concentration
5000 mcg/mL
Doses per vial
~2
Other stocked vial sizes: 20 mg.
Calculate with this peptide
References
- Lee C et al., Cell Metab, 2015.
- Reynolds JC et al., Nat Commun, 2021.
Related peptides in the Mitochondrial class
Frequently asked questions about MOTS-c
What is the typical research dose range for MOTS-c?
MOTS-c is most commonly investigated at 5.00 mg–10.0 mg per administration, weekly. Note: weekly research range, may also be split into 2x weekly. These values reflect documented research-stage protocols and are not medical recommendations.
What is the half-life of MOTS-c?
MOTS-c has an approximate plasma half-life of 2.5 hours. Practical steady state is reached after roughly five half-lives — about 1 days under continuous administration.
How is MOTS-c administered in research protocols?
Published research uses subq administration. Typical reconstitution is 10 mg vial in 2 mL of bacteriostatic water, producing a concentration of 5000 mcg/mL.
What vial sizes are commonly available for MOTS-c?
Common stocked vial sizes are 10 mg, 20 mg. The 10 mg vial is the most-used default in published protocols.