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Anti-inflammatory

L-Glutathione

A tripeptide (glycine-cysteine-glutamate) that is the dominant intracellular thiol antioxidant; investigated for systemic supplementation of redox capacity.

Also known as: GSH

Research consideration: Typically supplied as a 1800 mg/3 mL pre-mixed cartridge pen. Very short circulating half-life (~10 minutes).

Quick facts

Molecular weight

307 Da

Half-life

0.17 h

Frequency

daily

Admins / wk

7

Routes

SubQ / IM

Typical dose

100 mg–500 mg

Mechanism & positioning

A tripeptide (glycine-cysteine-glutamate) that is the dominant intracellular thiol antioxidant; investigated for systemic supplementation of redox capacity.

Researched for: cellular antioxidant capacity, phase-II hepatic conjugation.

Reconstitution defaults

Default vial

1800 mg

BAC water

3 mL

Concentration

600000 mcg/mL

Doses per vial

~18

Calculate with this peptide

References

  • Lu SC, Biochim Biophys Acta, 2013.

Related peptides in the Anti-inflammatory class

Frequently asked questions about L-Glutathione

What is the typical research dose range for L-Glutathione?
L-Glutathione is most commonly investigated at 100 mg–500 mg per administration, daily. Note: mg-scale; community range varies widely. These values reflect documented research-stage protocols and are not medical recommendations.
What is the half-life of L-Glutathione?
L-Glutathione has an approximate plasma half-life of 0.17 hours. Practical steady state is reached after roughly five half-lives — about 0 days under continuous administration.
How is L-Glutathione administered in research protocols?
Published research uses subq or im administration. Typical reconstitution is 1800 mg vial in 3 mL of bacteriostatic water, producing a concentration of 600000 mcg/mL.
What vial sizes are commonly available for L-Glutathione?
Common stocked vial sizes are 1800 mg. The 1800 mg vial is the most-used default in published protocols.
Anything important to know about L-Glutathione before designing a protocol?
Typically supplied as a 1800 mg/3 mL pre-mixed cartridge pen. Very short circulating half-life (~10 minutes).