Research use only. Read more

Cognitive

DSIP

A nonapeptide originally isolated from rabbit cerebral venous blood during slow-wave sleep; investigated for delta-EEG-active sleep induction and circadian research.

Also known as: Delta Sleep-Inducing Peptide

Research consideration: Very short plasma half-life (~7 minutes). Pre-sleep timing is conventional.

Quick facts

Molecular weight

850 Da

Half-life

0.12 h

Frequency

daily

Admins / wk

7

Routes

SubQ

Typical dose

100 mcg–500 mcg

Mechanism & positioning

A nonapeptide originally isolated from rabbit cerebral venous blood during slow-wave sleep; investigated for delta-EEG-active sleep induction and circadian research.

Researched for: delta-wave sleep modulation, circadian regulation (research models).

Reconstitution defaults

Default vial

10 mg

BAC water

2 mL

Concentration

5000 mcg/mL

Doses per vial

~100

Calculate with this peptide

References

  • Schoenenberger GA, Monnier M, PNAS, 1977.

Related peptides in the Cognitive class

Frequently asked questions about DSIP

What is the typical research dose range for DSIP?
DSIP is most commonly investigated at 100 mcg–500 mcg per administration, daily. Note: administered pre-sleep. These values reflect documented research-stage protocols and are not medical recommendations.
What is the half-life of DSIP?
DSIP has an approximate plasma half-life of 0.12 hours. Practical steady state is reached after roughly five half-lives — about 0 days under continuous administration.
How is DSIP administered in research protocols?
Published research uses subq administration. Typical reconstitution is 10 mg vial in 2 mL of bacteriostatic water, producing a concentration of 5000 mcg/mL.
What vial sizes are commonly available for DSIP?
Common stocked vial sizes are 10 mg. The 10 mg vial is the most-used default in published protocols.
Anything important to know about DSIP before designing a protocol?
Very short plasma half-life (~7 minutes). Pre-sleep timing is conventional.