Longevity
NAD+
A pyridine-nucleotide coenzyme central to cellular redox reactions and sirtuin signalling; investigated for systemic supplementation of declining endogenous NAD+ pools.
Also known as: Nicotinamide adenine dinucleotide
Research consideration: Often supplied as a pre-mixed cartridge pen at 1000 mg/3 mL or 1800 mg/3 mL.
Quick facts
Molecular weight
663 Da
Half-life
8 h
Frequency
weekly
Admins / wk
1
Routes
SubQ / IM
Typical dose
100 mg–500 mg
Mechanism & positioning
A pyridine-nucleotide coenzyme central to cellular redox reactions and sirtuin signalling; investigated for systemic supplementation of declining endogenous NAD+ pools.
Researched for: cellular redox, sirtuin co-substrate availability, mitochondrial function.
Reconstitution defaults
Default vial
500 mg
BAC water
5 mL
Concentration
100000 mcg/mL
Doses per vial
~5
Other stocked vial sizes: 1000, 1800 mg.
Calculate with this peptide
References
- Yoshino J et al., Cell Metab, 2018.
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Frequently asked questions about NAD+
What is the typical research dose range for NAD+?
NAD+ is most commonly investigated at 100 mg–500 mg per administration, weekly. Note: mg-scale per administration. These values reflect documented research-stage protocols and are not medical recommendations.
What is the half-life of NAD+?
NAD+ has an approximate plasma half-life of 8 hours. Practical steady state is reached after roughly five half-lives — about 2 days under continuous administration.
How is NAD+ administered in research protocols?
Published research uses subq or im administration. Typical reconstitution is 500 mg vial in 5 mL of bacteriostatic water, producing a concentration of 100000 mcg/mL.
What vial sizes are commonly available for NAD+?
Common stocked vial sizes are 500 mg, 1000 mg, 1800 mg. The 500 mg vial is the most-used default in published protocols.
Anything important to know about NAD+ before designing a protocol?
Often supplied as a pre-mixed cartridge pen at 1000 mg/3 mL or 1800 mg/3 mL.