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Growth Hormone

MGF

A mechanically-induced splice variant of IGF-1 with a unique C-terminal peptide investigated for activating muscle satellite cells in response to local tissue damage.

Also known as: Mechano Growth Factor, IGF-1Ec

Research consideration: Very short plasma half-life (~7 minutes) — research timing is typically immediately post-exertion at the target tissue.

Quick facts

Molecular weight

2,867 Da

Half-life

0.12 h

Frequency

daily

Admins / wk

7

Routes

SubQ / IM

Typical dose

200 mcg–400 mcg

Mechanism & positioning

A mechanically-induced splice variant of IGF-1 with a unique C-terminal peptide investigated for activating muscle satellite cells in response to local tissue damage.

Researched for: satellite cell activation, localised muscle repair.

Reconstitution defaults

Default vial

5 mg

BAC water

2 mL

Concentration

2500 mcg/mL

Doses per vial

~25

Calculate with this peptide

Documented pairwise interactions

  • caution

    MGF + IGF1-LR3

    Both signal through the IGF-1 receptor; co-administration is uncommon in published research and adds little novel signalling.

  • warning

    MGF + PEG-MGF

    Short-acting and pegylated forms of the same MGF molecule; combining them stacks receptor activity without literature support.

References

  • Goldspink G, Physiology, 2005.

Related peptides in the Growth Hormone class

Frequently asked questions about MGF

What is the typical research dose range for MGF?
MGF is most commonly investigated at 200 mcg–400 mcg per administration, daily. Note: post-exertion timing. These values reflect documented research-stage protocols and are not medical recommendations.
What is the half-life of MGF?
MGF has an approximate plasma half-life of 0.12 hours. Practical steady state is reached after roughly five half-lives — about 0 days under continuous administration.
How is MGF administered in research protocols?
Published research uses subq or im administration. Typical reconstitution is 5 mg vial in 2 mL of bacteriostatic water, producing a concentration of 2500 mcg/mL.
What vial sizes are commonly available for MGF?
Common stocked vial sizes are 5 mg. The 5 mg vial is the most-used default in published protocols.
Anything important to know about MGF before designing a protocol?
Very short plasma half-life (~7 minutes) — research timing is typically immediately post-exertion at the target tissue.